Dynactin 2 Proteins

Protein Information

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.

Synonyms

2310042E05Rik; 50 kDa dynein-associated polypeptide; C130077D06Rik; C87049; DCTN2; DCTN50; DCTN-50; dynactin 2; dynactin 2 (p50); dynactin complex 50 kDa subunit; Dynactin subunit 2; DYNAMITIN; epididymis secretory protein Li 77; GMP23-48K; Growth cone membrane protein 23-48K; HEL-S-77; p50; p50 dynamitin; RBP50